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Pharmaceuticals can produce opposite effects in tumor cells - the yin-yang effect
The effect of many agents used in tumor therapy is aimed to block the cell's own signaling cascades. When we studied the impact of selected drugs on the behavior of thyroid cancer cells, we found that one and the same substance can suppress the rate of cell division, while it increases the rate of cell migration (Fig. 6). - Such yin-yang effects should be considered in the treatment of tumors.
Figure 6: Application of inhibitor I leads to restrictions of the cellular activation status, as exemplified here for the proliferation and migration capacity. Depending on inhibitor and cell line used, yin-yang effects can appear: application of inhibitor II leads to a reduction in the proliferation rate, but increases the migration capacity. Circles represent the proliferation and migration capacity of tumor cells before (red) and after (blue, green) inhibitor administration.
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